A new method to increase longevity or treating cellular stress

• Over-expressing either pch-2 or bmk-1 in C. elegans by microinjection extends worm lifespan by ~25% and enhances worm survival survival in response to various stressors including oxidation, apoptosis and DNA damage.
• Inhibition of either gene by RNAi results in shortened lifespan. Moreover, the over-expression of the human equivalents of these two genes in cultured fibroblasts confers resistance to environmental stressors, and promotes cell survival after exposure to radiation or oxidative stress.
• Patent: US Patent Issued.
• Reference
  • Qian, H. et al., Aging (Albany NY). 2015 Jan; 7(1): 1-13;
  • Qian, H. et al., Oncotarget. 2015 Aug 7; 6(22): 18790-9.