- Overview of Your Current Project
Our research program broadly focuses on understanding the mechanisms involved in activating the appropriate cellular response at the intersection of DNA repair and apoptosis following DNA damage. A current major focus is to determine how the nucleotide excision repair (NER) factor, XPD controls the activation of apoptosis and NER in the presence of DNA damage. In recent work, we have discovered that XPD occupies a critical role in regulating a p53-independent mechanism that modulates survival/death decisions following triplex formation. This discovery unveiled an innovative strategy for the treatment of cancers characterized by gene amplification, in which manipulation of the DNA damage response with triplex-forming oligonucleotides (TFOs) drives tumor specific induction of apoptosis. DNA repair pathways have emerged as ideal targets for the development of cutting-edge anticancer therapeutics due to its role in both cancer progression and treatment. We have also developed a platform that utilizes natural products produced by fungal and bacterial endophytes to identify novel compounds with anticancer activity. We have recently discovered and chemically identified a novel DNA repair inhibitor that exhibits synthetic lethality in PTEN-deficient glioblastomas.
- Favorite Off-Time Activity
I enjoy spending time with my family, reading, and I have a love for music and watching TV (Major Game of Thrones fan).
- Best Advice for Young Innovators
Strive to use your failures as fuel to achieve success.