Lauren Cohn, MD

  • Associate Professor of Medicine (Pulmonary)
Research interests
Asthma; Epithelium; Lung; Lung Diseases; Metaplasia; Airway Management
Research summary

Dr. Cohn's research focuses on airway inflammation. Ongoing projects in the laboratory include (1) defining inflammatory pathways that inhibit allergic airway inflammation and asthma, (2) investigations of the airway epithelium in its contribution to lung inflammation, (3) immunologic pathways that provide protection in inflammatory diseases and mycobacterial infection.

Specialized Terms: Chronic inflammation in asthma; Mechanisms of mucus metaplasia; Airway epithelial functions in airway diseases and host defense

Education
  • MD, University of Minnesota, 1987
Publications
  • Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annual Review Of Immunology 2004, 22:789-815.
  • Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A novel pathway that regulates inflammatory disease in the respiratory tract. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178:3846-55.
  • Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106:9099-104.
  • Niu N, Laufer T, Homer RJ, Cohn L. Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183:1523-7.
  • Curran DR, Cohn L. Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease. American Journal Of Respiratory Cell And Molecular Biology 2010, 42:268-75.
  • Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. The Journal Of Experimental Medicine 2010, 207:2595-607.
  • Mitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 187:3815-20.
  • Cohn L, Hawrylowicz C, Ray A Chapter 13: Biology of Lymphocytes, in Middleton's Allergy: Principles and Practice ed 8 (In Press).