John Concato, MD

  • Professor of Medicine (General Medicine)
  • Director, Clinical Epidemiology Research Center, VA Connecticut HealthCare System

Dr. Concato has conducted numerous research projects evaluating the effectiveness of screening for prostate cancer and has helped to refine observational methods for evaluating screening tests in general. Other work, focusing on methods of patient-oriented research, compared the results of observational studies and randomized trials and found evidence (confirmed by other groups) contradicting suggestions of a simple “research design hierarchy.” Various studies have assessed prognosis in prostate cancer and clarified the use of multivariable analysis in analyzing data in patient-oriented research. As Director of the VA Clinical Epidemiology Research Center, ongoing work includes a portfolio of projects in the VA Cooperative Studies Program. In particular, he is one of two Principal Investigators on the VA Million Veteran Program that is developing a mega-biobank for genomic studies. Dr. Concato collaborates widely with other investigators across medical specialties, and he also mentors numerous trainees.

Research interests
Epidemiology; Internal Medicine; Prognosis; Research Design
Research summary

As a general internist and clinical epidemiologist, Dr. Concato conducts research to address questions related to screening, prognosis, and treatment strategies, as well as to improve methods of study design and statistical analysis. This dual focus has involved a range of topics in both patient care and research methodology. Examples include evaluating the effectiveness of screening for prostate cancer, studies of prognosis in prostate cancer, comparing the results of observational studies and randomized trials, and clarifying the use of multivariable analysis in patient-oriented research. More recent (“center-based”) research includes projects in genomic medicine, as part of the VA Cooperative Studies Program and Genomic Medicine Program.

Specialized Terms: Screening, prognosis, and treatment strategies; improving methods of research design and statistical analysis

Education
  • MD, New York University, 1985
Publications
  • Concato J. Study design and "evidence" in patient-oriented research. American Journal Of Respiratory And Critical Care Medicine 2013, 187:1167-72.
  • Concato J. Probability, uncertainty, and prostate cancer. Annals Of Internal Medicine 2013, 158:211-212.
  • Concato J. Is it time for medicine-based evidence? JAMA 2012, 307:1641-3.
  • Concato J, Lawler EV, Lew RA, Gaziano JM, Aslan M, Huang GD. Observational methods in comparative effectiveness research. The American Journal Of Medicine 2010, 123:e16-23.
  • Concato J, Wells CK, Horwitz RI, Penson D, Fincke G, Berlowitz DR, Froehlich G, Blake D, Vickers MA, Gehr GA, Raheb NH, Sullivan G, Peduzzi P. The effectiveness of screening for prostate cancer: a nested case-control study. Archives Of Internal Medicine 2006, 166:38-43.
  • Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. The New England Journal Of Medicine 2000, 342:1887-92.
  • 160. Gaziano M, Concato J, Brophy M, Fiore L, Pyarajan S, Breeling J, Whitbourne S, Deen J, Shannon C, Humphries D, Guarino P, Aslan M, Anderson D, LaFleur R, Hammond T, Schaa K, Moser J, Huang G, Muralidhar S, Przygodzki R, O’Leary TJ. J Clin Epidemiol 2016;70:214-223.