Vikki Abrahams, PhD

  • Associate Professor of Obstetrics, Gynecology, and Reproductive Sciences

Dr Vikki Abrahams received her B.Sc. (hons) in Immunology in 1996, and was awarded a Ph.D. in Immunology in 2000, both from University College London. She continued her studies as a postdoctoral associate at Dartmouth Medical School and then at Yale University in the field of Reproductive Immunology. In 2004 she joined the faculty in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale University. Since 2006 she has also been an Honorary Lecturer in the Maternal and Fetal Health Research Center at The University of Manchester, UK.

Dr Abrahams' research focuses on understanding the role of innate immune Toll-like receptor and Nod-like receptor family members in placental and maternal-fetal immune responses, and their role in regulating pregnancy outcome, including those complicated by infections and by autoimmune diseases. Studies from the Abrahams laboratory has characterized the mechanisms by which Toll-like receptors, Nod-like receptors, and the inflammasome function in the placental trophoblast and fetal membranes in response to both infectious and non-infectious stimuli.

Dr Abrahams is a member of the American Association of Immunologists, International Society for Immunology of Reproduction, Society for Reproductive Investigation, and the American Society of Reproductive Immunology. Dr Abrahams is the Associate Editor for Reviews of the American Journal of Reproductive Immunology and also serves on the editorial boards for a number of other journals within the Reproductive Sciences field.

Research interests
Autoimmune Diseases; Fetal Membranes, Premature Rupture; Immunity, Innate; Placenta; Pregnancy Complications; Pregnancy Complications, Infectious; Pregnancy in Diabetics; Antiphospholipid Syndrome; Antibodies, Antiphospholipid; MicroRNAs; Toll-Like Receptors; Nod Signaling Adaptor Proteins; Exosomes; Immune System Processes; Inflammasomes
Research summary

Dr Abrahams' research focuses on understanding the role of innate immune Toll-like receptor and Nod-like receptor family members in placental and maternal-fetal immune responses, and their role in regulating pregnancy outcome, including those complicated by infections and by autoimmune diseases. Studies from the Abrahams laboratory characterizes the mechanisms by which Toll-like receptors, Nod-like receptors, and the inflammasome function in the placental trophoblast and fetal membranes in response to both infectious and non-infectious stimuli.

Education
  • PhD, University College, London, 2000
Publications
  • Cross SN, Potter JA, Aldo P, Kwon JY, Pitruzzello M, Tong M, Guller S, Rothlin CV, Mor G, Abrahams VM. J Immunol. 2017 Sep 15. pii: ji1700870. doi: 10.4049/jimmunol.1700870. [Epub ahead of print]
  • Abrahams VM, Chamley LW, Salmon JE. Arthritis Rheumatol. 2017 Sep;69(9):1710-1721
  • Gysler SM, Mulla MJ, Guerra M, Brosens JJ, Salmon JE, Chamley LW, Abrahams VM. Mol Hum Reprod. 2016 Jul;22(7):465-74.27029214
  • Mhatre MV, Potter JA, Lockwood CJ, Krikun G, Abrahams VM. Am J Reprod Immunol. 2016 Jul;76(1):29-37
  • Potter JA, Garg M, Girard S, Abrahams VM. Viral single stranded RNA induces a trophoblast pro-inflammatory and antiviral response in a TLR8-dependent and -independent manner. Biol Reprod. 2015 Jan;92(1):17
  • Han CS, Herrin MA, Pitruzzello MC, Mulla MJ, Werner EF, Pettker CM, Flannery CA, Abrahams VM. Glucose and metformin modulate human first trimester trophoblast function: a model and potential therapy for diabetes-associated uteroplacental insufficiency. Am J Reprod Immunol. 2015 Apr;73(4):362-71
  • Alvarez AM, Mulla MJ, Chamley LW, Cadavid AP, Abrahams VM. Aspirin-triggered lipoxin prevents antiphospholipid antibody effects on human trophoblast migration and endothelial cell interactions. Arthritis Rheumatol. 2015 Feb;67(2):488-97
  • Hoang M, Potter JA, Gysler SM, Han CS, Guller S, Norwitz ER, Abrahams VM. Biol Reprod. 2014 Feb 27;90(2):39
  • Garg M, Potter JA, Abrahams VM. PLoS One. 2013 Oct 15;8(10):e77249
  • Mulla MJ, Salmon JE, Chamley LW, Brosens JJ, Boeras CM, Kavathas PB, Abrahams VM. PLoS One. 2013 Jun 6;8(6):e65237
  • Mulla MJ, Myrtolli K, Tadesse S, Stanwood NL, Gariepy A, Guller S, Norwitz ER, Abrahams VM. Am J Reprod Immunol. 2013 May;69(5):449-53.
  • Kavathas PB, Boeras CM, Mulla MJ, Abrahams VM. Mucosal Immunol. 2013 Mar;6(2):235-43.
  • Holder BS, Tower CL, Forbes K, Mulla MJ, Aplin JD, Abrahams VM. Immunology. 2012 Jun;136(2):184-91.
  • Cardenas I, Mulla MJ, Myrtolli K, Sfakianaki AK, Norwitz ER, Tadesse S, Guller S, Abrahams VM. J Immunol. 2011 Jul 15;187(2):980-6.