Biological Tools - Antibodies
This antibody was raised to a fusion protein representing the entire RAP protein (rat). Species reactivity is unknown. This antibody can be used for western blot, immunocytochemistry and immunoprecipitation. The characterization of this antibody has not been published. Megalin is a lipoprotein receptor expressed in kidney, CNS, lung, thyroid gland and possibly other tissues. In kidney, it functions as the primary mechanism for protein reabsorption. Our studies show megalin is subjected to regulated intramembrane proteolysis (similar to Notch) and thus may function as a signaling molecule as well as a receptor.
Zou et al., JBC 279:34302, 2004.