Research Tools

OCR 4773

Non-destructive MRI imaging of solids and MR image reconstruction algorithms.

OCR 3038

Nogo-B is a newly-discovered protein that is highly expressed in endothelial and smooth muscle cells of the vessel wall. Nogo-B has been shown to be a regulator of cell migration in vitro and of vascular remodeling in vivo. Molecules that mimic the activity of Nogo-B have been shown to be pro-angiogenic. More recently, the receptor for Nogo-B has been identified. Antagonists of the receptor have been shown to be anti-angiogenic, and therefore useful for the treatment of solid tumors. Work at Yale is underway to identify additional anti-angiogenic molecules.

OCR 5318

The advent of fluorescent proteins (FPs) has redefined the use of fluorescence microscopy in every biological discipline. Green fluorescent protein (GFP) and its variants are commonly used in celluar imaging studies. Recently, a novel fluorescent protein, named vivid Verde Fluorescent Protein (VFP), was isolated from Cyphastrea microphthalma, a scleractinian coral found in the warmer waters of the Australian Great Barrier Reef. The VFP sequence was modified for optimal fluorescence for use in a variety of molecular and biological applications.

OCR 1102

The invention is based on the discovery of various new IFT particle polypeptides and the genes that encode them.

OCR 4277

Efficient use of an in vitro produced chimeric mRNA and other modulator RNAs to create lymphocytes with high levels of specific cytotoxicity against chosen targets.

OCR 4575

Imprint lithography, based on the mechanical embossing of a polymer, can achieve pattern resolutions beyond the limitations set by the light diffractions or beam scattering in other techniques.

OCR 5095

Yale researchers have identified Wnt pathway agonists that are commercially available, but previously unassociated with the Wnt pathway activation. In addition, Yale researchers have identified novel members in the class. These compounds synergistically activate Wnt3a/Beta-catenin signaling and enhanced the activity of Wnt in vitro.

OCR 931

A novel tetrodotoxin resistant sodium channel is described, along with isolated nucleotides that encode this receptor. Methods for identifying agents that modulate the Na.sup.+ current through the receptor are provided, as well as related therapeutic and diagnostic methods.