Phage Therapy for Restoring Antibiotic Sensitivity to Bacterial Pathogens
Phage Therapy for Restoring Antibiotic Sensitivity to Bacterial Pathogens
P. aeruginosa causes infections that are notoriously difficult to manage due to low permeability of the outer membrane and antibiotic multi-drug efflux (Mex) system.
OMKO1 is a phage that utilizes OprM/Mex as a receptor-binding site.
Bacteriophage-induced selective pressure can reverse antibiotic resistance in multidrug resistant P. aeruginosa.
This phage has been used successfully to treat infections in more than 10 patients via compassionate use exemption.
Reference: Chan et al. (2016) Sci Rep
IP status: pending applications US16/095,041 and EP17790237.6
