A Novel Vaccine Candidate for Typhoid Fever

OCR Number: 
OCR 6185
  • Salmonella typhi causes typhoid fever, infecting tens of millions and killing hundreds of thousands of people every year.
  • The pathology is mediated by Typhoid toxin.
  • Current vaccines are only about 70-75% effective overall (CDC).
  • Need for more effective vaccines to prevent the contraction and spread of this disease.  
  • An inactivated version of the toxin can serve as the basis for the development of novel second-generation vaccines to treat typhoid fever.
  • In in vivo murine studies, OCR 6185 conferred full protection against typhoid fever after inoculation with Typhoid toxin, as shown in figure.
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