- Salmonella typhi causes typhoid fever, infecting tens of millions and killing hundreds of thousands of people every year.
- The pathology is mediated by Typhoid toxin.
- Current vaccines are only about 70-75% effective overall (CDC).
- Need for more effective vaccines to prevent the contraction and spread of this disease.
- An inactivated version of the toxin can serve as the basis for the development of novel second-generation vaccines to treat typhoid fever.
- In in vivo murine studies, OCR 6185 conferred full protection against typhoid fever after inoculation with Typhoid toxin, as shown in figure.