Neovascularization and Wound Healing

Inadequate blood vessel formation is a major contributor to poor wound healing particularly with diabetic ulcers.
Yale researchers have discovered that a unique domain from a known protein can promote VEGF signaling by associating with the VEGFR.
Injecting this 27 amino acid peptide (SP) i.p. in neonatal mice increased retinal vessel growth.
Topical application of the peptide to the injury site in mice after ear punch markedly enhanced the rate of wound healing.
A provisional patent application has been filed.