Materials & Nanotechnology
Yale researchers have identified that the acute inflammatory response to biomaterials can be limited by inhibition of inflammasome-related pathways.
~13nm nanowires with advantageous utility in electro-catalytic applications, e.g., fuel cells.
Polymer thin film spraying and coating techniques for enhanced power conversion in transparent electrodes, battery anodes and carbon photovoltaics.
More energy efficient capacitor-less ferroelectric DRAM devices replace end-of-life volatile memory.
Researchers at the University of Massachusetts Amherst and Yale University have recently developed a novel nanofabrication technology that provides high-resolution (up to ~106 ppi) mechanical and/or thermal sensor devices comprising individual or two-dimensional arrays of nanorods, nanotubes or nanowires. These nanoscale components are produced using polymers having excellent piezoelectric and/or pyroelectric properties, thus, exhibiting high-sensitivity responses to applied mechanical and/or thermal stimuli. This technology can be applied to a wide variety of two-dimensional sensing applications to enable high-resolution sensing currently unachievable with bulk polymer film based technologies. It can also be used for new electronic and biological applications that require mechanical and/or thermal stimuli-responsive nanoscale components or landscapes.
Methods for increasing the patency of biodegradable, synthetic vascular grafts are provided. The methods include administering one or more cytokines and/or chemokines that promote outward tissue remodeling of the vascular grafts and vascular neotissue formation. The disclosed methods do not require cell seeding of the vascular grafts, thus avoiding many problems associated with cell seeding. Biodegradable, polymeric vascular grafts which provide controlled release of cytokines and/or chemokines at the site of vascular graft implantation are also provided.
Yale investigators have developed a new synthetic platelet to treat hemorrhage. The synthetic platelet resembles the shape of an activated platelet (star burst) and is made from FDA-approved materials, consisting of a nanosphere core and polyethylene glycol (PEG) arms. Our synthetic platelet is capable of forming a barrier to reduce membrane permeability and enhance the sealing on a disrupted blood vessel wall, which is extremely beneficial to promote synthetic platelet aggregation at the site of injury.
Polymeric nanoparticles encapsulating inhibitory ribonucleic acids (RNAs) and methods of their manufacture and use are provided. Advantageous properties of the nanoparticles include: 1) high encapsulation efficiency of inhibitory RNAs into the nanoparticles, 2) small size of the nanoparticles that increases cell internalization, and 3) sustained release of encapsulated inhibitory RNAs by the nanoparticles that allows for administration of an effective amount of inhibitory RNAs to cells or tissues over extended periods of time. Encapsulation efficiency of inhibitory RNAs into the nanoparticles is greatly increased by complexing the inhibitory RNAs to polycations prior to encapsulation. Methods of using the polymeric nanoparticles for treating or inhibiting diseases or disorders are provided.