Development of a Novel HIV Bi-functional Therapeutic

OCR Number: 
OCR 5484
  • A small-molecule named “antibody-recruiting molecule targeting HIV-1 (analog 3)” (ARM-H-3) targeted for the treatment of HIV (240nM HIV antagonist).
  • Specifically both HIV (or HIV-infected CD4 T cells) and endogenous, well characterized, antibodies (anti-DNP).
  • Blocks HIV entry into cells as well as recruits antibodies.
  • Results in destruction of HIV and/or HIV-infected cells.
  • Provides advantages over protein-based therapeutics, such as large-scale production capabilities and low cost.
  • ARM-H-3 is a soluble drug-like compound derivative of a known HIV antagonist.
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