D-Dopachrome Tautomerase (D-DT): An Immune Response Regulator

OCR Number: 
OCR 5557
Description: 
  • D-dopachrome tautomerase (D-DT/MIF-2) is a homologue of the pivotal immune response regulator, macrophage migration inhibitory factor (MIF).
  • Clinical serum samples show that circulating levels of D-DT correlates with the severity of inflammatory disease and malignancy.
  • Anti-D-DT antibodies reduce circulating levels of pro-inflammatory cytokines, such as TNF-α, IFN-γ, IL-1β; while increasing concentrations of the anti-inflammatory cytokine IL-10 on target cells.
  • D-DT is an endogenous AMPK activator and is less likely to have off-target effects.
  • As shown in the figure, when administered 2 hours prior to LPS injection, D-DT antibody therapy increases survival in a mouse model of LPS-induced lethal endotoxemia.
  • OCR 5557 offers neutralizing monoclonal and rabbit polyclonal antibodies that are not cross-reactive with MIF.
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